GLP-1 medications have helped thousands of people lose weight and improve their health, but getting a prescription isn’t always straightforward. This guide will walk you through what it takes to qualify for a GLP-1 prescription, how to talk to your doctor, and how to get GLP-1 medication without insurance. By the end, you’ll know exactly what steps to take to advocate for yourself and get the treatment that’s right for you.
How Do GLP-1 Medications Work?
GLP-1 medications work by mimicking the body's natural hormones to regulate blood sugar, slow digestion, and reduce appetite. These medications mimic the glucagon-like peptide-1 (GLP-1) hormone, which naturally helps control appetite, slow digestion, and regulate insulin response. By keeping you fuller for longer and stabilizing blood sugar, GLP-1s can support sustainable weight loss, particularly for those who have struggled with diet and exercise alone.
Semaglutide and tirzepatide are currently the most effective options for weight loss, with once-weekly dosing and strong clinical results. While originally developed for diabetes management, below are some of the most common GLP-1 medications prescribed for weight loss:
Semaglutide (Ozempic, Wegovy, Rybelsus): One of the most popular options, semaglutide is highly effective for both diabetes and weight loss. It helps regulate blood sugar and significantly reduces appetite.
Tirzepatide (Mounjaro, Zepbound): A newer medication that targets both GLP-1 and GIP receptors, offering even greater appetite control and blood sugar benefits.
Liraglutide (Saxenda, Victoza): An older GLP-1 option, liraglutide requires daily injections and is approved for both weight loss and diabetes management.
Dulaglutide (Trulicity): Primarily prescribed for type 2 diabetes, this once-weekly injection may have some off-label use for weight management.
If you're considering GLP-1 medication, talk with your weight management doctor to determine which is best for your needs.
Do I Qualify for GLP-1?
To determine if GLP-1 medication is right for you, your doctor will consider the following:
Body Mass Index (BMI): If your BMI is 27 or higher with a weight-related condition like diabetes, hypertension, or sleep apnea, or 30 or higher without one.
Diabetes or Prediabetes: Certain GLP-1 medications are FDA-approved for managing type 2 diabetes or prediabetes.
Previous Weight Loss Attempts: If you have a history of trying to lose weight through diet and exercise, and those efforts have been unsuccessful.
Who Isn’t a Good Candidate for GLP-1?
While GLP-1 medications can offer significant benefits for weight management and diabetes control, they may not be suitable for everyone. You may not be a good fit for a GLP-1 prescription if:
You have a personal or family history of medullary thyroid carcinoma (MTC). GLP-1 medications carry a boxed warning regarding the risk of thyroid cancer, specifically medullary thyroid carcinoma (MTC). If you or a close family member have a history of MTC, you may be at increased risk and should discuss alternative treatment options with your healthcare provider.
You’ve been diagnosed with multiple endocrine neoplasia syndrome type 2 (MEN 2): This rare genetic condition predisposes individuals to certain cancers, including MTC. Because of the potential link between GLP-1 drugs and thyroid cancer, those with MEN 2 should avoid these medications.
You live with severe gastrointestinal disorders: GLP-1 medications work by slowing gastric emptying, which can exacerbate certain gastrointestinal issues. Conditions like gastroparesis, a disorder that affects stomach muscle function and delays stomach emptying, may worsen with GLP-1 use. If you have a severe gastrointestinal disorder, talk to your doctor about your options.
You’re taking medications that can have an adverse effect: GLP-1s can interact with other medications, particularly those affecting the digestive system or insulin. For instance, taking GLP-1 drugs alongside other medications that slow gastric emptying (such as some pain medications) could increase the risk of side effects. Always consult with your doctor about potential interactions before starting GLP-1 therapy.
Preparing for Your First Appointment with a Weight Management Doctor
The following information helps your doctor evaluate potential risks and medication interactions. To have a productive appointment, take these steps in advance.
Compile Medical History
Your doctor will need a complete picture of your health to determine if GLP-1 medication is right for you. Bring a detailed record that includes:
Pre-existing conditions such as diabetes, hypertension, PCOS
Family medical history detailing obesity, metabolic disorders, and endocrine conditions
Current medications including prescriptions, supplements, and over-the-counter drugs
Previous surgeries or procedures, particularly those related to weight loss or digestion (e.g., bariatric surgery)
Before your visit, familiarize yourself with GLP-1 medications like Wegovy, Ozempic, Zepbound, and Mounjaro. Understand the benefits, risks, and potential side effects in order to ask informed questions. Consider researching:
What the common side effects are and how long they typically last
What the long-term considerations like cost, sustainability, and lifestyle adjustments are
The documentation below helps justify the need for GLP-1 therapy and can strengthen your case for insurance coverage if applicable. Your doctor will need to know about your past weight loss efforts, so come prepared with:
Food and exercise log that tracks what you eat, your portion sizes, and activity levels.
A record of previous weight loss attempts—including diets, workout programs, or medications you've tried
Challenges you’ve faced such as emotional eating, metabolic issues, or time constraints.
Discussing financial considerations with your doctor can help you find the best solution within your budget. GLP-1 medications can be expensive, and insurance coverage varies. Before your appointment:
Check with your insurance provider to see if GLP-1s are covered under your plan
Research manufacturer savings programs from Novo Nordisk (Wegovy, Ozempic) or Eli Lilly (Zepbound, Mounjaro)
Explore compounded alternatives from reputable pharmacies if brand-name options are out of reach
How to Talk to Your Doctor About Weight Management Medication
Bringing up weight management medication with your doctor can feel overwhelming, but a clear and confident approach can lead to a productive discussion. Here’s how to prepare for the conversation and advocate for the best treatment plan for you.
Start by explaining your weight loss challenges and why you believe GLP-1 medication could be a good option. Show that you've done your research by mentioning key benefits, such as appetite regulation and metabolic improvements.
Be honest about your struggles with weight loss (including past diet and exercise attempts), your health concerns related to weight (such as diabetes, hypertension, or joint pain), and your goals, whether it’s improved overall health, increased energy, or sustainable weight loss.
Framing the conversation around your health and well-being can help your doctor see the bigger picture.
Take notes during the conversation to help you make an informed decision and compare options if needed.
What are the potential side effects, and how can they be managed?
How long will I need to take GLP-1s? Is this a long-term or short-term solution?
What happens if I stop taking the medication? Will I regain weight?
Should I make lifestyle changes alongside the medication? What role do diet and exercise play in its effectiveness?
Every medication has trade-offs, and you’ll want to discuss the potential benefits and risks with your doctor based on your unique health history. While there is a potential for side effects like nausea, digestive discomfort, and fatigue, many patients find the pros outweigh the cons.
Common benefits include increased mobility, improved self-esteem and self-confidence as well as the potential to reduce the need for medications that lower cholesterol and blood pressure.
If you or your weight management doctor raise concerns about side effects, ask about ways to minimize them, such as starting with a lower dose or adjusting your diet.
If your doctor is hesitant to prescribe a GLP-1, ask about other weight management options, including:
Metabolic testing to assess how your body processes food and determine if underlying issues are affecting weight loss.
Structured lifestyle interventions, including medical nutrition therapy or supervised weight loss programs.
Bariatric procedures if medically appropriate, such as gastric sleeve or bypass surgery.
Keeping an open mind will allow you to explore a range of solutions that align with your health needs and long-term goals.
How to Get GLP-1 Medication Without Insurance
If you don’t have insurance, there are still ways to access GLP-1 medications at a lower cost.
Compounded GLP-1s – OrderlyMeds and other specialty pharmacies offer compounded versions of tirzepatide and semaglutide at a fraction of the price. These compounded versions also allow for a personalized approach to medicine and can help minimize side effects compared to brand names.
Pharmacy Discounts – Platforms like GoodRx, SingleCare, and Cost Plus Drugs provide coupons and lower cash prices at major pharmacies.
Clinical Trials – Some research studies offer free access to GLP-1s. Check ClinicalTrials.gov for opportunities.
Exploring these options can help make treatment more affordable. Talk with your weight management specialist or pharmacist to find the best path for you.
Get GLP-1 Online from OrderlyMeds
OrderlyMeds offers a convenient, affordable way to access GLP-1 medications without insurance obstacles. Through our online prescription service, you can consult with a licensed provider and, if approved, receive your medication hassle-free. Join a community thousands strong and get started today.